The Neurosurgical Center Nijmegen is dedicated to both clinical and basic science research in collaboration with other departments and study groups of the Radboud University Medical Center and other hospitals as well.

Actual Research project:

Cerebellar Mutism

Trigeminal anatomy and central neuropathic pain

Within the Neurosurgical Center Nijmegen itself, the research activities can be grouped in the following major areas:

  • Development of neurosurgical instruments and innovative operative techniques
  • Cranial Nerve Research
  • Peripheral Nerve Research
  • Spine Research
  • Neuro-oncology
  • Pain modulation
  • Hydrocephalus and congenital disorders
  • Trauma

Development of neurosurgical instruments and innovative operative techniques

The ongoing improvement of neurosurgical techniques and the development of minimally invasive neurosurgery and neuroendoscopy require further sophistication and development of neurosurgical instruments and techniques. The NCN wants to attribute to this field by focusing on the safety of neurosurgical procedures with reduction of the invasiveness of surgery as well as improving the ergonomics of the neurosurgical techniques. Significant contributions have already been made in the neuroendoscopic treatment of hydrocephalus with the development of the Grotenhuis perforator and dilator for endoscopic III. ventriculocisternostomy. Also, a new head fixation clamp that allows intraoperative re-positioning of the patients head and has perfect X-ray compatibility was developed together with Zeppelin Chirurgische Instrumente GmbH.

The NCN is world-leading with the integration of a Head-Mounted-Display into neuroendoscopy.

Current research studies:

  • Research on the application of new methods for neuronavigation (fluoroscopy, ultrasound, infrared) and development of endoscope-navigation
  • Applied ergonomics for neurosurgery
  • Evaluation of the use of a Head-Mounted-Display in neurosurgery
  • Development of an innovative endoscopic approach to pituitary disorders and instrumentation development for endoscopic pituitary surgery
  • Analysis of methods for neurosurgical hemostasis
  • Robotics in neurosurgery (International collaborative study)
  • Clinical study on the use of a new dural sealant

Cranial Nerve Research

The NCN has initiated the world-wide first Cranial Nerve Research Center, a multidisciplinary team that studies the pathophysiology of cranial nerve disorders and their treatment.

Current research studies:

  • Prospective analysis of the olfactory system in anterior cranial fossa surgery
  • Prospective randomized trial on microvascular decompression in therapy-refractory arterial hypertension
  • Prospective cohort-study on the value of microvascular decompression for unaccountable progressive visual acuity loss
  • Analysis of fibrin sealant coating of cranial nerves during cranial surgery

Peripheral Nerve Research – current studies

  • Study of the role of the EMG in clinically evident carpal tunnel syndrome
  • Participation in DUNE trial: a prospective randomized trial comparing conservative treatment versus surgical treatment of mild ulnar neuroapthy at the elbow.

Spine Research – current studies

  • Randomized controlled trial of anterior single-level cervical disc surgery followed by cervical disc prosthesis, or carbon cage spondylodesis or no disc substitute at all. (PROCON trial)
  • Participation in a multi-center study of minimally invasive treatment of lumbar herniated disc with the METRx-system.
  • Randomized controlled trial comparing laminectomy without fusion versus lamincetomy with dorsal instrumented fusion for patients with symptomatic cervical stenosis (LAMIFUSE).
  • Participation in an international multi-center observational study on the surgical treatment of cervical spinal stenosis. (AO Spine)

Neuro-oncology – current studies

  • Evaluation of results of endoscopic surgery for pituitary adenomas
  • Retrospective study on treatment results in AT/RT (atypical teratoid/rhabdoid tumor) in children
  • Genetic studies in gliomas

Pain modulation – current studies

  • Analysis of electrostimulation in the epidural space in chronic pain treatment
  • Study of motor cortex stimulation in chronic pain patients

Hydrocephalus and congenital disorders – current studies

  • Analysis of the effectivity of endoscopic hydrocephalus treatment
  • Analysis of the value of brain specific proteins in estimating cerebral neuronal damage in hydrocephalus
  • Prospective study on prognostic factors in spina bifida aperta
  • Development of a meningomyelocele model in sheep and exploration of the possibility of fetal surgical repair of meningomyelocele in a sheep model (multidisciplinary study with gynecology, urology and biochemistry
  • Exploration of the possibility of fetal surgery in humans

Trauma – current studies

  • The influence of rotation therapy on intracranial pressure in head trauma
  • Participation in a Multi Center Trial for the value of dexanabinol in brain trauma treatment
  • Multimodality monitoring in head-/brain trauma
  • Analysis of the value of brain specific proteins in determining the extent of cerebral damage in head trauma